Can getting the shingles vaccine reduce your risk of Alzheimer’s disease? Is it really worth getting the shot?
A study published in Nature on April 2, 2025 analyzed the health records of more than 280,000 older adults in Wales and found that those who received a shingles vaccine had a 20% lower risk of developing dementia (including Alzheimer’s) over the next seven years—a 3.5-percentage-point absolute reduction. Another 2024 study in Nature Medicine reported that recipients of the recombinant shingles vaccine (Shingrix) experienced, on average, a 164-day longer dementia-free period compared with older vaccines. While these observational findings suggest the vaccine may protect the brain—possibly by reducing varicella-zoster virus reactivation, with a stronger effect seen in women—they do not establish cause and effect. Below, we’ll unpack what this means and answer the big question: should you get the shingles vaccine? Table of Contents Vaccine Lowers Risk—but Isn’t a Guarantee Had Shingles Already? Should You Still Get Vaccinated? Never Had Shingles? Is Vaccination Necessary? Dos...