Microglia , the primary immune cells in the brain, have long been regarded as key players in maintaining neural health. However, as research into Alzheimer's disease (AD) has deepened, increasing evidence suggests that microglia may not only protect but also potentially drive the progression of the disease. This article delves into the dual roles of microglia in Alzheimer's disease, examining how they can transition from guardians to potential threats, and explores future therapeutic directions. Key Points Role of Microglia in a Healthy Brain: Microglia maintain brain homeostasis through surveillance, phagocytosis, and repair of damage. Microglial Activation in Alzheimer's Disease: Microglial responses to amyloid plaques and tau tangles may contribute to neuroinflammation. Protective vs. Harmful Roles: Microglia may have protective effects early on but could exacerbate neurodegeneration with chronic activation. Therapeutic Potential: Treatments targeting microglia are...
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